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From: "Craig Niederberger" <craigni@att.net>
To: <androlog@uic.edu>
Subject: Diet and male reproduction references
Date: Mon, 10 Mar 2003 18:55:43 -0600
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As promised, I'm sending out the references collected by my "diet and
male

fertility" post. This is made easy by the extensive work previously
done

by several individuals who graciously shared their references. As
you've

seen in a previous post by Dr. Ghanem (and communicated to my privately
by

Dr. Lipshultz), a review was published several years ago in Fertily and

Sterility:

=20

Wong W, Thomas C, Merkus J et al. Male factor subfertility: possible
causes

and impact of nutritional factors. Fertility Sterility. Vol 73, No 3,

435-442. March 2000.

=20

Dr. Roudebush provided a detailed and extensive set of references (many

thanks):

=20

Abell A, Ernst E, Bonde JP. High sperm density among members of organic

farmers=92 association. Lancet 1994;343:1498.

=20

Aquino R, De Feo V, De Simone F, et al. Plant metabolites, new compounds

and antiinflammatory activity of Uncaria tomentosa. J Nat Prod

1991;54:453-9.

=20

Aydin S, Inci O, Alagol B. The role of arginine, indomethacin and

kallikrein in the treatment of oligoasthenospermia. Int Urol Nephrol

1995;27:199-202.

=20

Bayer R. Treatment of infertility with vitamin E. Int J Fertil
1960;5:70-8.

=20

Carpino A, Siciliano L, Petroni MF, et al. Low seminal zinc bound to
high

molecular weight proteins in asthenozoospermic patients: evidence of

increased sperm zinc content in oligoasthenozoospermic patients. Hum
Reprod

1998;13:111-4.

=20

Costa M, Canale D, Filicori M, et al. L-carnitine in idiopathic

asthenozoospermia: a multicenter study. Andrologia 1994;26:155-9.

=20

Czeizel AE. Periconceptual folic acid containing multivitamin

supplementation. Eur J Obstet Gynecol Reprod Biol 1998;78(2):151-61.

=20

Danscher G, Hammen R, Fjerdingstad E, Rebbe H. Zinc content of human

ejaculate and motility of sperm cells. Int J Androl 1978;1:576-81.

=20

Dawson EB, et al. Effect of ascorbic acid supplementation on the sperm

quality of smokers. Fertil & Steril 1992;58(5):1034-9.

=20

Dawson EB, Harris WA, Teter MC, Powell LC. Effect of ascorbic acid

supplementation on the sperm quality of smokers. Fertil Steril

1992;58:1034-9.

=20

Dawson EB, Harris WA, McGanity WJ. Effect of ascorbic acid on sperm

fertility. Fed Proc 1983;42:531 [abstr 31403].

=20

Dawson EB, Harris WA, Powell LC. Relationship between ascorbic acid and

male fertility. In: Aspects of Some Vitamins, Minerals and Enzymes in

Health and Disease, ed. GH Bourne. World Rev Nutr Diet 1990;62:1-26

[review].

=20

Dawson EB, Harris WA, Rankin WE, et al. Effect of ascorbic acid on male

fertility. Ann N Y Acad Sci 1987;498:312-23.

=20

De Aloysio D, Mantuano R, Mauloni M, Nicoletti G. The clinical use of

arginine aspartate in male infertility. Acta Eur Fertil 1982;13:133-67.

=20

Fraga CG, Motchnik PA, Shigenaga MK, et al. Ascorbic acid protects
against

endogenous oxidative DNA damage in human sperm. Proc Natl Acad Sci

1991;88:11003-6.

=20

Geva E, Bartoov B, Zabludovsky N, et al. The effect of antioxidant

treatment on human spermatozoa and fertilization rate in an in vitro

fertilization program. Fertil Steril 1996;66:430-4.

=20

Hartoma TR, Nahoul K, Netter A. Zinc, plasma androgens and male
sterility.

Lancet 1977;2:1125-6.

=20

Hong CY, Chiang BN, Turner P. Calcium ion is the key regulator of human

sperm function. Lancet 1984;2:1449-51.

=20

Hruska KS, Furth PA, Seifer DB, et al. Environmental factors in

infertility. Clin Obstet Gynecol 2000;43:821-9.

=20

Keplinger H. Oxyindole alkaloids having properties stimulating the

immunologic system and preparation containing same. US Patent no.

5,302,611, April 12, 1994.

=20

Kessopoulou E, et al. A double-blind randomized placebo cross-over

controlled trial using the antioxidant vitamin E to treat reactive
oxygen

species associated with male infertility. Fertil & Steril

1995;64(4):825-31.

=20

Kilic S, Sarica K, Yaman O, et al. Effect of total and ionized calcium

levels of seminal fluid on sperm motility. Urol Int 1996;56:215-8.

=20

Kumamoto Y, Maruta H, Ishigami J, et al. Clinical efficacy of
mecobalamin

in treatment of oligozoospermia. Acta Urol Jpn 1988;34:1109-32.

=20

Kvist U, Kjellberg S, Bjorndahl L, et al. Seminal fluid from men with

agenesis of the Wolffian ducts: zinc-binding properties and effects on

sperm chromatin stability. Int J Androl 1990;13:245-52.

=20

Kynaston HG, Lewis-Jones DI, Lynch RV, Desmond AD. Changes in seminal

quality following oral zinc therapy. Andrologia 1988;20:21-2.

=20

Lewin A, Lavon H. The effect of coenzyme Q10 on sperm motility and

function. Mol Aspects Med 1997;18 Suppl:S213-9.

=20

Marmar JL, Katz S, Praiss DE, DeBenedictis TJ. Semen zinc levels in

infertile and postvasectomy patients and patients with prostatitis.
Fertil

Steril 1975:26:1057-63.

=20

Martin-Du Pan RC, Sakkas D. Is antioxidant therapy a promising strategy
to

improve human reproduction? Are anti-oxidants useful in the treatment of

male infertility? Hum Reprod 1998;13:2984-5.

=20

Moncada ML, Vicari E, Cimino C, et al. Effect of acetylcarnitine
treatment

in oligoasthenospermic patients. Acta Europaea Fertilitatis
1992;23:221-4.

=20

Moriyama H, et al. Studies on the usefulness of a long-term, high-dose

treatment of methylcobalamin in patients with oligozoospermia. Hin Kiyo

1987;33(1):151-6.

=20

Mroueh A. Effect of arginine on oligospermia. Fertil Steril
1970:21:217-9.

=20

Omu AE, Dashti H, Al-Othman S. Treatment of asthenozoospermia with zinc

sulphate: andrological, immunological and obstetric outcome. Eur J
Obstet

Gynecol Reprod Biol 1998;79:179-84.

=20

Piacentino R, Malara D, Zaccheo F, et al. Preliminary study of the use
of

s. adenosyl methionine in the management of male sterility. Minerva

Ginecologica 1991;43:191-3 [in Italian].

=20

Prasad AS, Cossack ZT. Zinc supplementation and growth in sickle cell

disease. Ann Intern Med 1984;100:367-71.

=20

Prien SD, Lox CD, Messer RH, DeLeon FD. Seminal concentrations of total
and

ionized calcium from men with normal and decreased motility. Fertil
Steril

1990;54:171-2.

=20

Pryor JP, Blandy JP, Evans P, et al. Controlled clinical trial of
arginine

for infertile men with oligozoospermia. Br J Urol 1978;50:47-50.

=20

Rolf C, Cooper TG, Yeung CH, Nieschlag E. Antioxidant treatment of
patients

with asthenozoospermia or moderate oligoasthenozoospermia with high-dose

vitamin C and vitamin E: a randomized, placebo-controlled, double-blind

study. Hum Reprod 1999;14:1028-33.

=20

Rizzi R, Re F, Bianchi A, et al. Mutagenic and antimutagenic activities
of

Uncaria tomentosa and its extracts. J Ethnopharmacol 1993;38:63-77.

=20

Roudebush WE, et al.. Fertile One supplementation will significantly

improve the total number of morphological normal-motile sperm in male

factor patients. ASRM 2003;submitted.

=20

Roudebush WE, Witt MA, Davis AL, Combs BF, Massey JB, Toledo AA.
Improved

sperm motility and percent normal morphology following L-carnitine and

acetyl-L-carnitine diet supplementation. J Androl 2003;in press.

=20

Saaranen M, Suistomaa U, Kantola M, et al. Lead, magnesium, selenium and

zinc in human seminal fluid: comparison with semen parameters and

fertility. Hum Reprod 1987;2:475-9.

=20

Salvati G, Genovesi G, Marcellini L, et al. Effects of Panax ginseng
C.A.

Meyer saponins on male fertility. Panmineva Med 1996;38:249-54.

=20

Sandler B, Faragher B. Treatment of oligospermia with vitamin B12.

Infertility 1984;7:133-8.

=20

Salvati G, Genovesi G, Marcellini L, et al. Effects of Panax ginseng
C.A.

Meyer saponins on male fertility. Panmineva Med 1996;38:249-54.

=20

Schacter A, Goldman JA, Zukerman Z. Treatment of oligospermia with the

amino acid arginine. J Urol 1973;110:311-3.

=20

Schacter A, Friedman S, Goldman JA, Eckerling B. Treatment of
oligospermia

with the amino acid arginine. Int J Gynaecol Obstet 1973;11:206-9.

=20

Scibona M, Meschini P, Capparelli S, et al. L-arginine and male

infertility. Minerva Urol Nefrol 1994;46:251-3.

=20

Scott R , MacPherson A, Yates RWS, et al. The effect of oral selenium

supplementation on human sperm motility. Br J Urol 1998;82:76-80.

=20

Stankovic H, Mikac-Devic D. Zinc and copper in human semen. Clin Chim
Acta

1976;70:123-6.

=20

Takihara H, et al. Zinc sulphate therapy for infertile male with or

without varicocelectomy. Urol 1987;29(6):638-41.

=20

Tanimura J. Studies on arginine in human semen. Part II. The effects of

medication with L-arginine-HCl on male infertility. Bull Osaka Med
School

1967;13:84-9.

=20

Tanimura J. Studies on arginine in human semen. Part III. The influences
of

several drugs on male infertility. Bull Osaka Med School 1967;13:90-100.

=20

Thiessen DD, Ondrusek G, Coleman RV. Vitamin E and sex behavior in mice.

Nutr Metab 1975;18:116-9.

=20

Tikkiwal M, Ajmera RL, Mathur NK. Effect of zinc administration on
seminal

zinc and fertility of oligospermic males. Indian J Physiol Pharmacol

1987;31:30-4.

=20

Vitali G, Parente R, Melotti C. Carnitine supplementation in human

idiopathic asthenospermia: clinical results. Drugs Exp Clin Res

1995;21:157-9.

=20

Wollock LM, Tamura T, et al. Low seminal plasma folate concentrations
are

associated with low sperm density and count in male smokers and
nonsmokers.

Fertil Steril 2001;75:252-9.

=20

Wong WY, Merkus HM, et al. Effects of folic acid and zinc sulfate on
male

factor subfertility: a double-blind, randomized, placebo-controlled
trial.

Epidemiology 2002;13:184-90.

=20

Wong WY, et al. Male factor subfertility: possible causes and the impact
of

nutritional factors. Fertil Steril 2000;75:435-42.

=20

Zhang JP, Meng QY, Wang Q, et al. Effect of smoking on semen quality of

infertile men in Shandong, China. Asian J Androl 2000;2:143-6.

=20

Zheng R-L and Zhang H. Effects of ferulic acid on fertile and

asthenozoospermic infertile human sperm motility, viability, lipid

peroxidation, and cyclic nucleotides. Free Rad Biol & Med
1997;22(4):581-6.

=20

Dr. Fugh-Berman provided a number of references on Ginseng (many
thanks):

=20

Awang DVC. The neglected ginsenosides of North American ginseng (Panax

quinquefolius L.). J Herbs Spices Med Plants 2000;7(2):103-109.

=20

Bahrke MS, Morgan WP. Evaluation of the ergogenic properties of ginseng:
an

update. Sports Med 2000;29(2):113-133.

=20

Baldwin CA, Anderson LA, Phillipson JD et al. What pharmacists should
know

about ginseng. Pharm J 1986;237:583-86.

=20

Choi HK, Seong DH, Rha KH. Clinical efficacy of Korean red ginseng for

erectile dysfunction. Int J Impotence Res 1995;7:181-86.

=20

Cui J, Garle M, Eneroth P, Bjorkhem I. What do commercial ginseng

preparations contain? Lancet 1994;344:134.

=20

Dega H, Laporte J-L, Frances C et al. Ginseng as a cause for Stevens-

Johnson syndrome? Lancet 1996; 347:1344.

=20

Duda RB, Zhong Y, Navas V et al. American ginseng and breast cancer

therapeutic agents synergistically inhibit MCF-7 breast cancer cell
growth.

J Surg Onc 1999;72:230-39.

=20

Duda RB. Taback B, Kessel B et al. PS2 expression induced by American

ginseng in MCF-7 breast cancer cells. Ann Surg Onc 1996;3(6) :515-20.

=20

Gonzalez-Seijo JC, Ramos YM, Lastra I. Manic episode and ginseng: report
of

a possible case. J Clin Psychopharmacol 1995;15(6):447.

=20

Greenspan EM. Ginseng and vaginal bleeding. Journal of the American
Medical

Association 1983; 249:2018

=20

Gross D, Krieger D, Efrat R, Dayan M. Ginseng extract G115 for the

treatment of chronic respiratory diseases. Schweis Zschr
GhanheitsMedezin

1995;1:29-33.

=20

Hammond TG, Whitworth JA. Adverse reactions to ginseng. Med J Australia

1981;1:492.

=20

Hiai S, Yokoyama H, Oura H, Yano S. Stimulation of
pituitary-adrenocortical

system by ginseng saponin. Endocrinol Japon 1979;26(6):661-65.

=20

Hopkins MP, Androff L, Bennighoff AS. Ginseng face cream and unexplained

vaginal bleeding. American Journal of Obstetrics and Gynecology 1988;

159:1121-22.

=20

Jones BD, Runikis AM. Interaction of ginseng with phenelzine. J Clin

Pharmacol 1987;7(3)::201-202.

=20

Lee FC, Ko JH, Park JK, Lee JS. Effects of Panax ginseng on blood
alcohol

clearance in men. Clin Exp Pharm Phys 1987;14:543-46.

=20

Marasco C, Ruiz V, Villagomez S, Infante B. Double-blind study of a

multivitamin complex supplemeted with ginseng extract. Drugs Exp Clin
Res

1996;22(6):323-329.

=20

Mills S, Bone K. Principles and Practice of Phytotherapy Churchill-

Livingstone, Edinburgh 2000418-432 Palmer BV, Montgomery ACV, Monteiro

JCMP. Gin Seng and mastalgia. BMG 1978;1(6122)1284.

=20

Park H-J, Rhee M-H, Park K-M et al. Effect of non-saponin fraction from

Panax ginseng on cGMP and thromboxane A2 in human platelet aggregation.
J

Ethnopharm 1995;49:157-62.

=20

Pearce PT, Zois I, Wynne KN, Funder JW. Panax ginseng and
Eleutherococcus

senticosus extracts in vitro studies on binding to steroid receptors.

Endocrinol Japan 1982;29(5):567-73.

=20

Punnonen R, Lukola A. Oestrogen like effect of ginseng. British Medical

Journal 1980; 281:1110.

=20

Ryu S-J, Chien Y-Y. Ginseng-associated cerebral arteritis. Neurology

1995;45:829-30.

=20

Shader RI, Greenblatt DJ. Phenelzine and the dream machine ramblings and

reflections. J Clin Psychopharmacol 1985;5:65.

=20

Salvati G, Genovesi G, Marcellini L et al. Effects of Panax ginseng CA

Meyer on male fertility. Panminerva Med 1996;38:249-54.

=20

Scaglione F, Weiser K, Alessandria M. Effects of the standardized
ginseng

extract G115=AE in patients with chronic bronchitis. Clin Drug Invest

2001;21(1):41-45.

=20

Scaglione F, Cattaneo G, Alessandria M, Cogo R. Efficacy and safety of
the

standardized ginseng extract G115 for potentiating vaccination against

common cold and/or influenza syndrome. Drugs Exptl Clin Res 1996; XXII

(2):65-72.

=20

See DM, Broumand N, Sahl L, Tilles JG. In vitro effects of echinacea and

ginseng on natural killer and antibody-dependent cell cytotoxicity in

healthy subjects and chronic fatigue syndrome or acquired
immunodeficiency

syndrome patients. Immunopharmacology 1997;35:229-35.

=20

Siegel RK. Ginseng abuse syndrome: problems with the panacea. JAMA

1979;241:1614-15.

=20

Sonnenborn U, H=E4nsel R. Panax ginseng. In De Smet PAGM, Keller K,
H=E4nsel

R, Chandler RF. Adverse Effects of Herbal Drugs, volume 1, 1992:179-191.

=20

Sotaneimi EA, Haapokoski E, Rautio A. Ginseng therapy in non-insulin-

dependent diabetic patients. Diabetes Care 1995;18(10):1373-75.

=20

Thommessen B, Laake K. No identifiable effect of ginseng (Gericomplex)
as

an adjuvant in the treatment of geriatric patients. Aging Clin Exp Res

1996;8:417-20.

=20

Tode T, Kikuchi Y, Kita T et al. Inhibitory effects by oral
administration

of ginsenoside Rh 2 on the growth of human ovarian cancer cells in nude

mice. J Cancer Res Clin Onc 1993:120:24-26.

=20

Vuksan V, Sievenpiper JL, Wong J et al. American ginseng (Panax

quinquefolius L.) attenuates postprandial glycemia in a time-dependent
but

not dose-dependent manner in healthy individuals. Am J Clin Nutr.

2001;73(4):753-8.

=20

Vuksan V, Sievenpiper JL, Koo VY et al. American ginseng (Panax

quinquefolius L) reduces postprandial glycemia in nondiabetic subjects
and

subjects with type 2 diabetes mellitus. Arch Intern Med.

2000a;160(7):1009-13.

=20

Vuksan V, Stavro MP, Sievenpiper JL et al. Similar postprandial glycemic

reductions with escalation of dose and administration time of American

ginseng in type 2 diabetes. Diabetes Care. 2000b;23(9):1221-6.

=20

Wichtl Wiklund IK, Mattsson LA, Lindgren R, Limoni C. Effects of a

standardized ginseng extract on quality of life and physiological

parameters in symptomatic postmenopausal women: a double-blind, placebo-

controlled trial. Swedish Alternative Medicine Group.Int J Clin
Pharmacol

Res. 1999;19(3):89-99.

=20

Yun TK, Choi SY. A case-control study of ginseng intake and cancer. Int
J

Epi 1990;19:871-76.

=20

Yun YS, Lee YS, Jo SK, Jung IS. Inhibition of autochthonous tumor by

ethanol-insoluble fraction from Panax ginseng as an immunomodulator.
Planta

Med 1993;59:521-24.

=20

Yun TK, Choi SY. Preventive effect of ginseng intake against various
human

cancers: a case-control study on 1987 pairs. Cancer Epi Biomarkers Prev

1995;4:401-08.

=20

Yun TK. Experimental and epidemiological evidence of the
cancer-preventive

effects of Panax ginseng CA Meyer. Nutrition Reviews 1996;54;S71-S81.

=20

Zhu M, Chan KW, Ng LS, et al. Possible influences of ginseng on the

pharmacokinetics and pharmacodynamics of warfarin in rats. J Pharm

Pharmacol 1999;51:175-80.

=20

Again, many thanks to those who responded.

=20

Craig Niederberger

=20

~~~~~~~~~~~~~~~~~~~~~~~~~~~~~ craign@uic.edu ~~~~~~~~~~~~~~~~~~~~~~~~~

Craig Niederberger MD FACS | Chief, Division of Andrology

University of Illinois at Chicago | Urology Residency Program Director

Department of Urology M/C 955 | 312-996-2779 Fax: 360-838-1823
840

South Wood St, Chicago IL 60612 | http://godot.urol.uic.edu

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charset="iso-8859-1"
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<html>

</head>

As promised, I'm sending out the references collected by my =
"diet
and male

fertility" post.=A0 This is made easy by the extensive work
previously done

by several individuals who graciously shared their =
references.=A0 As
you've

seen in a previous post by Dr. Ghanem (and communicated to my =
privately
by

Dr. Lipshultz), a review was published several years ago in =
Fertily and

Sterility:

Wong W, Thomas C, Merkus J et al. Male factor subfertility: =
possible
causes

and impact of nutritional factors.=A0 Fertility Sterility. Vol =
73, No 3,

435-442. March 2000.

Dr. Roudebush provided a detailed and extensive set of =
references (many

thanks):

Abell A, Ernst E, Bonde JP. High sperm =
density
among members of organic

farmers’ association. Lancet =
1994;343:1498.

Aquino R, De Feo V, De Simone F, et al. =
Plant
metabolites, new compounds

and antiinflammatory activity of Uncaria tomentosa. J Nat =
Prod

1991;54:453-9.

Aydin S, Inci O, Alagol B. The role of arginine, indomethacin =
and

kallikrein in the treatment of oligoasthenospermia. Int Urol =
Nephrol

1995;27:199-202.

Bayer R. Treatment of infertility with vitamin E. Int J Fertil =
1960;5:70-8.

Carpino A, Siciliano L, Petroni MF, et al. =
Low
seminal zinc bound to high

molecular weight proteins in asthenozoospermic patients: =
evidence of

increased sperm zinc content in oligoasthenozoospermic patients. =
Hum Reprod

1998;13:111-4.

Costa M, Canale D, Filicori M, et al. =
L-carnitine
in idiopathic

asthenozoospermia: a multicenter study. Andrologia =
1994;26:155-9.

Czeizel AE.=A0 Periconceptual folic acid containing =
multivitamin

supplementation.=A0 Eur J Obstet Gynecol Reprod Biol =
1998;78(2):151-61.

Danscher G, Hammen R, Fjerdingstad E, Rebbe H. Zinc content of =
human

ejaculate and motility of sperm cells. Int
J Androl 1978;1:576-81.

Dawson EB, et al. Effect of ascorbic =
acid
supplementation on the sperm

quality of smokers. Fertil & Steril =
1992;58(5):1034-9.

Dawson EB, Harris WA, Teter MC, Powell LC. =
Effect of
ascorbic acid

supplementation on the sperm quality of smokers. Fertil =
Steril

1992;58:1034-9.

Dawson EB, Harris WA, McGanity WJ. Effect of =
ascorbic
acid on sperm

fertility. Fed Proc 1983;42:531 [abstr 31403].

Dawson EB, Harris WA, Powell LC. Relationship =
between
ascorbic acid and

male fertility. In: Aspects of Some Vitamins, Minerals and =
Enzymes in

Health and Disease, ed. GH Bourne. World Rev Nutr Diet =
1990;62:1-26

[review].

Dawson EB, Harris WA, Rankin WE, et al. Effect of ascorbic acid =
on male

fertility. Ann N Y Acad Sci 1987;498:312-23.

De Aloysio D, Mantuano R, Mauloni M, Nicoletti G. The clinical =
use of

arginine aspartate in male infertility. Acta Eur Fertil =
1982;13:133-67.

Fraga CG, Motchnik PA, Shigenaga MK, et al. Ascorbic acid =
protects
against

endogenous oxidative DNA damage in human sperm. Proc Natl Acad =
Sci

1991;88:11003-6.

Geva E, Bartoov B, Zabludovsky N, et al. The effect of =
antioxidant

treatment on human spermatozoa and fertilization rate in an in =
vitro

fertilization program. Fertil Steril =
1996;66:430-4.

Hartoma TR, Nahoul K, Netter A. Zinc, plasma androgens and male
sterility.

Lancet 1977;2:1125-6.

Hong CY, Chiang BN, Turner P. Calcium ion is the key regulator =
of human

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Again, many thanks to those who responded.

Craig Niederberger

~~~~~~~~~~~~~~~~~~~~~~~~~~~~~ craign@uic.edu =
~~~~~~~~~~~~~~~~~~~~~~~~~

Craig Niederberger MD FACS=A0=A0=A0=A0=A0=A0=A0=A0=A0 | Chief, =
Division of Andrology

University of Illinois at Chicago=A0=A0 | =
Urology Residency
Program Director

Department of Urology M/C 955=A0=A0=A0=A0=A0=A0 | =
312-996-2779=A0=A0 Fax: 360-838-1823
840

South Wood St, Chicago IL 60612 |
http://godot.urol.uic.edu>

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