Androlog Mail:
>I have a couple of cases of prolonged, and sometimes permanent,
>hypogonadism in men treated with LHRH agonists (Lupron, Zoladex)...
>Jay Sandlow, MD
>jay-sandlow@uiowa.edu
Look in:
Radner-H et al: Neuropathol-Appl-Neurobiol. 1991 Feb; 17(1): 75-81.
They report a case of a 78-year-old male who was treated with goserelin
(Zoladex) for 16 months for metastasizing prostate carcinoma. They found
diffuse, partially nodular hyperplasia of growth hormone (GH) and
adrenocorticotropin (ACTH) producing cells in the anterior pituitary gland
at autopsy. As Zoladex reduces pituitary receptors for releasing hormones
(RH), a globally increased hypothalamic secretion of RH might be responsible
for the ACTH- and the GH-cell hyperplasia. The authors concluded that
Zoladex may cause (nodular) hyperplasia of the pituitary gland in man.
Harald Trummer MD
Department of Urology, Graz Austria
harald.trummer@kfunigraz.ac.at
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