Androlog Mail:
>Does any one out there have any info or experience in patients who have
>had total pelvic irradiation and then go on to attempt a conception
>utilising donor eggs? If so, does the DXT in any way affect the uterus
>and obviously implantation and pregnancy rates?
>Lawrence Gobetz
>e-mail- Lawgob@icon.co.za
Pelvic radiotherapy effectively affects the uterus, inducing fibrosis and
lesions of the vessels.
In cohort studies, an excess of adverse obstetrical outcome has been shown
in fertile women treated by pelvic irradiation during childhood: spontaneous
abortion, in utero death, premature birth, low birth weight.
Moreover, Critchley and coll. studied women castrated by high dose pelvic
irradiation (20 to 30 Gy)during childhood, and showed that the endometrium
of these women did not response to estrogenic stimulation.
CRITCHLEY H.O.D. et al. Abdominal irradiation in childhood and the potential
for pregnancy. Brit J Obstet Gynaecol 1992,99:392.
GREEN D.M. et al. Offspring of patients treated for unilateral Wilm's tumor
in childhood. Cancer 1982,49:2285.
HAWKINS M.M., SMITH R.A. Pregnancy outcome in childhood cancer
survivors:probable effect of abdominal irradiation. Int J Cancer 1989,43:399.
LI F.P. et al. Outcome of pregnancy in survivors of Wilm's tumor. J.A.M.A.
1987,257:216.
Dominique MARMOR M.D.
Unite de Medecine de la Reproduction
Hopital Saint-Antoine 75012-PARIS
FRANCE
Dominique.marmor@sat.ap-hop-paris.fr
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